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and the associated Stimuli article have been approved for publication in Pharmacopeial Forum 40(1) [Jan.–Feb. Both are being presented in advance of publication of PF 40(1) to allow additional time for public review and comment.

Comments will be accepted until March 31, 2014, the end of the comment period for Pharmacopeial Forum 40(1).

Dissolution test parameters were considered appropriate when a most discriminative release profile for fluconazole capsules was yielded.

The dissolution performance test is a required test for all solid oral dosage forms for product release testing.

It also is used commonly as a predictor of a drug product's in-vivo performance.

The purpose of this study is to develop and validate a dissolution test for fluconazole, an antifungal used for the treatment of superficial, cutaneous, and cutaneomucous infections caused by Candida species, in capsules dosage form.

Techniques by HPLC and UV first derivative spectrophotometry (UV-FDS) were selected for quantitative evaluation.




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